role of erk5 in neuronal survival pathway
| PAG Title | role of erk5 in neuronal survival pathway |
| PAG ID | WAG000640 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | Axons extend significant distances to innervate target tissues. At the site of innervation, target tissues release neurotrophins including NGF, BDNF and neurotrophin-3 that stimulate the survival of the associated neuron. Local sigling by activated Trk receptors at the syptic terminus mediates some presyptic neurol responses to neurotrophins. Map kise pathways activated by Trk receptor activate Erk1 and Erk2 at the terminus stimulating axol growth, and PI3K activates AKT in the terminus as well. Activation of these kises does not propagate a sigl to the cell body though and does not induce a transcriptiol response. This local sigling at the terminus or local sigling at the cell body appears distinct from the sigling pathway that transduces the survival sigl from the target tissue. |
| Species | Homo sapiens |
| nCoCo Score | 4,060 |
| Base PAG ID | WAG000640 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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